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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STAT3 All Species: 31.52
Human Site: S540 Identified Species: 86.67
UniProt: P40763 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40763 NP_003141.2 770 88068 S540 L G P G V N Y S G C Q I T W A
Chimpanzee Pan troglodytes XP_511505 786 90098 S537 L G P G V N Y S G C Q I T W A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_849765 770 88039 S540 L G P G V N Y S G C Q I T W A
Cat Felis silvestris
Mouse Mus musculus P42227 770 88035 S540 L G P G V N Y S G C Q I T W A
Rat Rattus norvegicus P52631 770 88021 S540 L G P G V N Y S G C Q I T W A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q6DV79 771 88152 S540 L G P G V N Y S G C Q I T W A
Frog Xenopus laevis Q9PVX8 769 87956 S540 L G P G V N Y S G C Q I T W A
Zebra Danio Brachydanio rerio NP_571554 806 92133 S541 L G P C V N Y S G C Q I T W A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24151 761 86396 D514 R D P F M I T D R V T W A Q L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.8 N.A. 99.4 N.A. 99.8 99.7 N.A. N.A. 97.5 95.8 83.2 N.A. 22.9 N.A. N.A. N.A.
Protein Similarity: 100 96.1 N.A. 99.8 N.A. 100 100 N.A. N.A. 98.4 97.7 88.2 N.A. 40.9 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 100 100 93.3 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 100 100 93.3 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 89 % A
% Cys: 0 0 0 12 0 0 0 0 0 89 0 0 0 0 0 % C
% Asp: 0 12 0 0 0 0 0 12 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 89 0 78 0 0 0 0 89 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 12 0 0 0 0 0 89 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 89 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % L
% Met: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 89 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 89 0 0 12 0 % Q
% Arg: 12 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 89 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 12 0 0 0 12 0 89 0 0 % T
% Val: 0 0 0 0 89 0 0 0 0 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 12 0 89 0 % W
% Tyr: 0 0 0 0 0 0 89 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _